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Our research seeks to understand how impaired function of human adipose tissue contributes to cardiometabolic diseases such as obesity and type 2 diabetes. Healthy adipose tissue safely stores excess energy as fat and releases it when needed. In many individuals, however, this capacity becomes compromised, leading to dysfunctional fat storage and mobilization that contribute to insulin resistance, type 2 diabetes, and cardiovascular disease.

To uncover the mechanisms underlying these processes, we conduct deeply phenotyped clinical studies in which adipose tissue biopsies are collected from research participants and analyzed using state-of-the-art experimental approaches. By combining human intervention studies with functional analyses of freshly isolated adipocytes, we generate unique datasets that directly link human physiology to the cellular mechanisms driving metabolic disease.

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