Upstream Small-Scale Senior Scientist

  • Company:
    Sanofi
  • Location:
  • Salary:
    negotiable / monthly
  • Job type:
    Full-Time
  • Posted:
    1 week ago
  • Category:
    Biotech / Science

Upstream Small-Scale Senior Scientist Reference #: 2461171 Department: ACEL Center of Expertise Location: North York, Ontario About Sanofi Pasteur Sanofi Pasteur, the vaccines division of Sanofi, is the largest company in the world devoted entirely to human vaccines. Our driving goal is to protect people from infectious diseases by creating safe and effective vaccines.  Our company distributes more than 1 billion doses of vaccine each year, making it possible to vaccinate more than 500 million people across the globe.  Sanofi Pasteur offers the broadest range of vaccines in the world, providing protection against 20 bacterial and viral diseases. Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.  With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Job Summary: Maintain and enhance the scientific expertise in industrial upstream processes. Optimize and characterize the antigen production processes (upstream) and the processing of the antigens (downstream). Ensure the robustness, reliability, scalability and cost effectiveness of the overall processes. Test and implement new technologies/processes where appropriate. Key Accountabilities: Management (20%) Network with local and global experts/ SPPs as necessary, leveraging knowledge/data where possible. Assist with the discussions and interactions with the regulatory agencies where require. In coordination with the MTech lab manager, coordinate technologists activities. 30 to 50% of the presence time in the lab. Upstream Process, Troubleshooting and Technology Evaluation (40%) Deep knowledge in microbiology and in microbial metabolism. Proven track records in industrial fermentation process development (batch, fed-batch, continuous) and technology, f rom 100mL up to at least 150L scale. High cell density culture. Evaluation/suitability of use of SUF solutions. Process scale up/scale down. Prepare risk assessment and gap analysis. Establish program for method development. Be a creative force to bring new, pragmatic and holistic approach to process development & troubleshooting. Critical analysis of processes and proactively seek for solutions facilitating the downstream processing of the antigens. Technological survey. Improve the use of PAT for process monitoring and analysis. Project & Transversal Interactions (30%) Responsible for delivering against agreed-upon project objectives and to the agreed-upon quality standards. As an Expert in biotechnological processes, ensure that the technical propositions are in accordance with the industrial constraints, are robust, reliable and economically advantageous. Ensure that process bottlenecks are identified. Strive to establish reliable scale-down model of the processes implemented in manufacturing. Work with other groups to identify/understand the opportunities for new and optimized production processes. Ensure that all innovative or rationalization ideas that could be proposed are within the industrial property policies of the group. Challenge the scientific content of the studies performed in the MTech lab. Be a communication and collaboration facilitator between the departments. Raw Materials and Media/Downstream (10%) Take into account risk assessments and gap analysis related to raw materials. Proven track records in medium development. By identifying metabolic limitations. By characterizing the antigen expression. By defining growth medium limiting the use of complex and/or animal origin raw material. Be a creative force for taking into account the raw material impact on the downstream process. Compliance and Safety Work within the framework of the Manufacturing Technology Team (i.e: respecting schedule, phase gates, decision processes, design review deadlines, team culture, communication, documents, etc) with professionalism and transparency and delivering in a timely manner in accordance with the design and execution schedule requirements. Ensure operating procedures are current and followed, and site and corporate policies are adhered to. Ensure the project is carried out in a safe manner and safety issues are effectively resolved. Improve safety by a day to day presence in the lab. Supervises and monitors compliance with employment and health and safety legislation to ensure that employees work within the policies, procedures and regulations applicable to their work. Participates in the investigation of incidents and work-related illnesses. Responds promptly to all health and safety concerns or incidents and completes the appropriate documentation in a timely manner. Takes every reasonable precaution to ensure the health and safety of staff. Ensures that protective equipment and clothing required is used by staff. Cooperates and assists the Joint Health and Safety Committee in carrying out its functions. Advises staff of any potential or actual health and safety hazard of which they are aware. Education: Minimum MSc., PhD. or equivalent in Biotechnology processes or Chemical Engineering & Microbiology. Experience: 8-10+ years direct experience in upstream process development in pharma/biotech organization. 5+ years demonstrated leadership in behavioral competencies and management. Hours of Work: Monday to Friday: 8:00 – 4:00 p.m. Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to a ttract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants.  Accommodations for persons with disabilities required during the recruitment process are available upon request. Thank you in advance for your interest. Only those candidates selected for interviews will be contacted. Sanofi, Empowering Life  #GD-SP            #LI-SP Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Sanofi, Empowering Life